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In addition, curcumin binds to the catalytic pocket and induces pocket compaction

Yerbes R, Mora-Molina R, Fernndez-Farrn FJ, Hiraldo L, Lpez-Rivas A, Palacios C

Food and Chemical Toxicology, 50, 20272033

The thermal gradient started at 50 C and was held for 1 min (corresponding to the solvent delay) to minimize peak broadening of early-eluting analytes
