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In vitro studies have characterised its effects on decorin expression, fibronectin production, and gene expression profiles associated with extracellular matrix biology

There are several mechanisms which may underlie the association between type II diabetes and dementia, including neurotoxicity resulting from hyperglycemia, alterations in amyloid metabolism, increased risk of cerebrovascular disease, and a combination of these mechanisms (6)

Pyridoxine (vitamin B6) is sometimes combined for additional metabolic and nervous system support