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This mechanistic difference is central to why the two are studied as a pair

B12 shots are recommended for anyone with vitamin B12 deficiency, including those with digestive issues or autoimmune disorders that prohibit them from absorbing B12 orally
American Journal of Epidemiology

Thus, the GVB barrier controls the translocation of antigens of various sizes from the gut into the bloodstream and, in particular, prevents the penetration of intestinal microbiota into the portal bloodstream (Spadoni et al., 2015)
