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doi:10.1074/jbc.R113.458810

Vitamin C induces ferroptosis in anaplastic thyroid cancer cells, which suggests its potential as a therapeutic agent

In this study, CGA improved the activity of mitochondrial complexes I, IV, and V by enhancing the levels of SOD and mitochondrial glutathione in the brain, inhibited the activation of Bax and caspase-3 (proapoptotic proteins), increased the expression of Bcl-2 (an antiapoptotic protein), and prevented the MPTP-mediated apoptotic cascade
