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AcvB associates with the membrane via the Trp378- and Leu379-containing hydrophobic loop, orienting the Ser336-containing catalytic site toward the membrane surface

Science 338 , 13441348 (2012)

In this context, taurine appears to attenuate As2O3 mediated toxicity (249), possibly by reducing the expression levels of phosphorylated JNK kinases, thereby ruling out the possibility that hepatic cells follow the apoptotic route after taurine treatment in As2O3-administered rats (248)

With the relaxation of the STITCH confidence constraint, one pair of high-priority synthetic lethals was associated with disulfiram: LmjF25.1170 & LmjF25.1180 , genes encoding F-type H+-transporting ATPase beta chain
