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Furthermore, at 2A -adrenergic receptors, DA functions as a biased ligand, preferentially signaling via G protein recruitment but not through -arrestin2, providing a new mechanism for DAs intracellular signaling at these receptors

Vascular-Metabolic Risk Factors and Psychological Stress in Patients with Chronic Tinnitus

For most researchers, the practical answer is: pick the form that matches your priorities

Thats true for animal models, so that principle would definitely carry over to human clinical trials as well
