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The acetyl group on aspirin is hydrolzed and then bonded to the alcohol group of serine as an ester

found that TMAO can inhibit the RCT process and affect cholesterol metabolism ( ApoE / mice, and further activate the nuclear receptors farnesoid-X-receptor (FXR) and small heterodimer partner (SHP), to reduce the expression of cholesterol 7-hydroxylase (Cyp7a1) to inhibit bile acid synthesis, thus accelerating the formation of atherosclerosis ( coprostanol (a bacterial metabolite of cholesterol) ( Figure 3 Potential Therapeutic Measures of TMAO for AS Reduced Production of TMAO to Protect the Heart TMAO is an intestinal microbiota-dependent metabolite, which is accumulated in the body by ingestion of large amounts of substances rich in phosphatidylcholine

SevcsikE.PabstG.RichterW.DannerS.AmenitschH.LohnerK.2008Interaction of LL-37 with Model Membrane Systems of Different Complexity: Influence of the Lipid Matrix