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Tirzepatide is the first dual GLP-1/GIP receptor co-agonist which has been approved for treatment of type 2 diabetes mellitus (T2DM) based on the findings from the SURPASS program
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The results of immunofluorescence and WB showed that knocking down of Bcl-2 antagonized the recovery of ZO-1 in IECs following HSYA treatment (Supplementary Figures S2D, S2E)
