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Description
Oncotarget 7 , 2714227157 (2016)
This observation has been reported in earlier studies in obese and hyperinsulinemic subjects, and in patients with Cushings syndrome, in whom hepatic sensitivity to GH is increased when compared to lean subjects (95, 103)
However, contrary to expectations, the deletion of the Nfe2l2 gene had a moderate impact on the course of the disease in SOD1 G93A mice and negatively affected only a few Nrf2-regulated antioxidant enzymes, thus suggesting that several Nrf2-target genes can also be regulated independently of Nrf2 in ALS mice [270, 271]
Hewlings S, Kalman D
