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Thus, a vicious cycle is established in which aging, while imposing neurological changes intrinsic to advanced age and increasing susceptibility to circadian disturbances, also contributes to the worsening of chronodisruption by impairing the SCNs ability to synchronize with environmental stimuli
SRDFM: Siamese response deep factorization machine to improve anti-cancer drug recommendation
For example, for drug interaction via phase I enzymatic inhibition, substrate levels in plasma increases but metabolite levels decreases (Dresser et al., 2000
doi: 10.1016/j.pbb.2018.12.006
