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Structural basis and regulation of the reductive stress response

Kim Y, Kim YS, Kim HY, Noh M-Y, Kim JY, Lee Y-J, Kim J, Park J, Kim SH (2018) Early treatment with Poly(ADP-Ribose) Polymerase-1 inhibitor (JPI-289) reduces infarct volume and improves long-term behavior in an animal model of ischemic stroke

Similarly, in the 6-OHDA-treated rat PD model, an increase in microglia, activation of astrocytes, loss of dopaminergic neurons, and significant upregulation of pro-inflammatory factors (IL-1, IL-6, TNF- , IFN- ) were observed, alongside a decrease in anti-inflammatory factor levels