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We hypothesize that reduced CPT-I activity may contribute to persistent fatigue in these congenital hypothyroid patients, even after levothyroxine therapy, which alone may be insufficient to fully address the downstream metabolic consequences of TPO and TSHR gene mutations present in this cohort

Violante S, Ijlst L, Te Brinke H, Koster J, Tavares de Almeida I, Wanders RJA, et al