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The PPAQ group significantly reduced oxidative stress parameters and inflammatory biomarkers, demonstrating its antioxidant and anti-inflammatory effects

Physiological or pharmacological elevation of hepatic FGF21 induces the expression and secretion of insulin-like growth factor-binding protein 1 (IGFBP1) in the liver, IGFBP1 in turn functions as an endocrine hormone by binding to its receptor integrin 1 on osteoclast precursors, and stimulates osteoclast differentiation and bone resorption by potentiating RANKL-induced ERK phosphorylation and NFATc1 activation, thus leading to lower bone mass

The direct function includes the binding of the thiol group to free radicals, hydrogen peroxide and hypochlorite to clear ROS

Part of the knowledge generated on glutathione in Arabidopsis may not be completely transferable to other species (eg, because of specificity of defense pathways)