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For instance, blood samples from 72 colorectal cancer patients showed a significant reduction in epithelial markers (EpCAM, CK19, and CEA) in CTCs compared to tumor tissue, indicating that most CTCs lose their epithelial phenotype in the bloodstream

However, despite significant advancements in biochemical and molecular techniques in recent years, no specific and targeted antifibrotic treatment strategies have been approved, potentially due to the complicated molecular mechanism that initiates and drives the fibrotic events, which remains to be completely understood

[DOI] [PubMed] [Google Scholar] Lu MC, et al