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Abdelhalim MAK, Moussa SAA, Qaid HA, Al-Ayed MS

Autonomic nervous system dysfunction (ANSD) is a relevant contributor to some of the clinical features in RTT patients that leads to multiple impairments ranging from anxiety, GI dysfunction, breathing disturbances, peripheral vascular control alteration (19) to sleep issues (3), heart rate variability (HRV) (2022), and increased risk of sudden death (23, 24)

Therefore, pharmacological doses of coenzyme Q 10 as high as 1,200 to 3,000 mg/day for adults and 30 mg/kg/day for children are usually needed to relieve symptoms in patients with coenzyme Q 10 deficiency (26)

However, liquid, as well as powders, can have a bitter aftertaste, making the pill form more appealing to some