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doi: 10.1038/nm836 34 LutzHUStammlerPBianchiVTrebRMHunzikerTBurgerRet al

Aspirin and the potential role of prostaglandins in colon cancer

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This review systematically summarizes the functional mechanisms of key signaling regulators involved in cancer metabolic reprogramming, including mammalian target of rapamycin complex 1 (mTORC1), myelocytomatosis viral oncogene homolog (c-Myc), hypoxia-inducible factor-1 (HIF-1), activating transcription factor 4 (ATF4), nuclear factor erythroid 2related factor 2 (NRF2), and sterol regulatory elementbinding protein 1 (SREBP1)