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Some studies have linked the initial onset of angular cheilitis with nutritional deficiencies, especially of the B (B2-riboflavin) vitamin and iron (which causes iron deficiency anemia), [12] which in turn may be evidence of malnutrition or malabsorption

TBI, stroke and a disrupted sleepwake cycle are the nonspecific environmental factors most likely to be linked to the onset of the disease in a broader sense, as all of these could transiently or permanently modulate hypocretin levels [29]

Choline: An essential nutrient crucial for lipid metabolism and neurotransmitter synthesis