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In mouse models, the loss of thioredoxin reductase 2 (Txnrd2) results in an endothelial phenotype that promotes thrombosis, as Txnrd2-deficient mice develop widespread microthrombi in arteries, arterioles, and capillaries, suggesting a systemic tendency toward thrombosis [46]

doi: 10.1177/1933719116667226 29 HafeziMArabipoorAGhaffariFVesaliSZareeiMHessariZH

There are three activities of the MTHFD1 encoded enzyme that include, N 5 , N 10 -methenyl-THF (5,10-methenyl-THF) cyclohydrolase, 5,10-methylene-THF dehydrogenase, and 10-formyl-THF synthetase

Significant decreases were also noted in primary autoantibodies such as total IgG, anti-2 glycoprotein I (anti-2GPI), and anti-dsDNA (162)