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81 Notably, a substantial fraction of tryptophan is directed through the Kyn pathway, culminating in the production of a suite of metabolites with significant physiological implications

10.1016/S0889-8529(05)70340-6 Endocrinol

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It is also commonly acknowledged that through synaptic transmission (also known as neurotransmission), the CNS can control smooth, skeletal, and cardiac muscles, bodily secretions, and organ functions [12,13,14]
