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Second, Munc13-4 also binds the Rab GTPases Rab27a and Rab11 but ENDOs do not disturb these interactions
Mercer TR, Munro T, Mattick JS
However, in primary oligodendrocyte cell cultures from 12-day-old rats, CBD (100 nM1 M) resulted in mitochondrial dysfunction that led to increases in intracellular cytotoxic Ca 2+ and ROS, which negatively impacted oligodendrocyte viability (Mato et al., 2010)
For example, in in vitro studies, shRNA is often used to silence the expression of metabolic enzymes to observe their effects on ammonia metabolism, whereas in vivo , the affected sites may be more numerous and complex
