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The moderately elevated levels of 4-HNE ( 45 M) [161]

3.3.1 Mitochondrial fusion and regulatory mechanisms Mitochondrial fusion is a cellular self-repair mechanism that combines healthy mitochondria with damaged or mutated mitochondria to repair the damage or compensate for the mitochondrial dysfunction caused by mutations through complementary effects, thus ensuring normal mitochondrial function and maintaining normal cellular physiological activities (Twig and Shirihai, 2011)

[DOI] [PMC free article] [PubMed] [Google Scholar] 178.Schallreuter K.U., Wood J.M

For MMUT to function properly, a third protein, MMAA, is required to protect MMUT against oxidative stress and to reactivate the enzyme [107]