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These include capsaicin (reduces the level of a pain transmitter called Substance P), SAMe or S-adenosylmethionine (an endogenous compound that stimulates cartilage production), and anthocyanidins (an antioxidant that prevent the degradation of collagen)
ABHD5 stimulates PNPLA1-mediated - O -acylceramide biosynthesis essential for a functional skin permeability barrier
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