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It is derived from several observations, including the inability of antibodies to minor populations of surface proteins for example, antibodies to NA on influenza viruses or to an altered conformation of the rabies G protein to neutralize the corresponding viruses owing to insufficient coating of virions

Because collagen acts as the structure that holds everything up, a lack of it causes skin to sag or wrinkle

[2] "Glucose-6-phosphate dehydrogenase deficiency: MedlinePlus Genetics"
