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Paolicelli RC, Paolicelli RC, Bolasco G, Pagani F, Maggi L, Scianni M, et al

Nature 580 , 576577 (2020)

CJC-1295 vs tesamorelin Tesamorelin (Egrifta) is an FDA-approved GHRH analog used to reduce abdominal fat in HIV patients with lipodystrophy

Key dosing points from the study: Dose range: 200500 mcg per session (individual variation based on severity and body weight) Frequency: 23 sessions per week during the active treatment phase Duration: 48 weeks of active treatment Route: Local subcutaneous injection proximal to the affected joint Concurrent therapy: Most patients continued physical therapy alongside BPC-157 treatment The combination of local administration and physical therapy aligns with the hypothesis that BPC-157 accelerates structural repair while functional loading (exercise) guides proper tissue remodeling