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In this protein adduct pathway NAPQI primarily targets mitochondrial proteins and ion channels, leading to the loss of energy production, disturbances in ionic balance, and ultimately cell death

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The first is the antioxidant barrier: polyphenols establish antioxidant defense by activating the Nrf2 signaling pathway, and Nrf2 upregulates the expression of HO-1, SOD-1, NQO-1 and other oxidative genes, so as to increase the number of antioxidant enzymes (SOD/CAT/GPX/GSH), and to neutralize cisplatin-induced reactive oxygen species (ROS) and reactive nitrogen species (RNS)

CXCR3 promotes plaque formation and behavioral deficits in an Alzheimers disease model