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Contracting skeletal muscle acts as an endocrine organ that releases a diverse array of bioactive factors, often termed exerkines, including myokines, metabolites, growth factors, and extracellular vesicles

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Therefore, while aware that the pharmacological modulation of the NRF2/ARE pathway could undeniably offer new therapeutic opportunities for diseases related to OS, we should at the same time consider that most of the currently known activators of NRF2 are not particularly specific, leading to an increased risk of off target toxic effects