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Based on this mechanism, normalizing excess glutamate levels by metabotropic glutamate group 2/3 receptor agonists has led to potential identification of the first non-monoaminergic target with comparable efficacy as conventional antipsychotic drugs for treating positive and negative symptoms of schizophrenia

This can mean that the material is not easily eliminated from the body The cause of constipation is often not known

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In severe cases, a person suffering from dehydration may experience low blood pressure, fever, rapid breathing, or a rapid heartbeat