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Description
Anaphylaxis and Other Hypersensitivity Reactions Following Administration of Monoclonal Antibodies for Treatment of Malignant Disease Recent information suggests that increasing use of monoclonal antibodies to target cancer is associated with a considerable number of severe infusion reactions[23] that are disruptive of patient care.[24] In the case of cetuximab (Erbitux), a high prevalence of hypersensitivity reactions has been reported.[25] These reactions are reportedly due to IgE antibodies to cetuximab and, specifically, to galactose--1,3-galactose present on the recombinant cetuximab.[26] Therefore, oncologists should become knowledgeable regarding the pathophysiology as well as the treatments and diagnostic aids for anaphylaxis summarized herein

Marriott B.M., editor

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