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doi: 10.2188/jea.10.79
When it was recognized that pellagra, a condition marked by diarrhea, dermatitis, dementia, and mortality, could be treated with foods containing NAD+ precursors, particularly vitamin B3, the clinical significance of maintaining NAD+ levels was established in the early 1900s
Lower level deficiency has been associated with a range of symptoms such as fatigue, memory impairment, irritability, depression and personality changes
