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Studies on SARS-CoV-1 to explain why dimerization is required for activity have revealed that, in the monomeric state, the active site pocket collapses and is not available for substrate binding and processing 7
Pang L, Yeung O, Ng K, Liu H, Zhu J, Liu J, et al

[DOI] [PMC free article] [PubMed] [Google Scholar] 12.Ray A, James MK, Larochelle S, Fisher RP, Blain SW, p27Kip1 inhibits cyclin D-cyclin-dependent kinase 4 by two independent modes

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