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Key Mechanistic Differences# The mechanistic distinction is significant: Dihexa promotes structural synaptic plasticity through growth factor signaling (building new connections), while PE-22-28 modulates functional neuronal properties through ion channel blockade (changing how existing neurons fire)

promoted cardiomyocyte survival (PMID: 25015963) Wound Healing: Accelerated wound closure, reduced scarring in dermal wound models (PMID: 25015963, PMID: 27450738) Corneal: Enhanced corneal epithelial healing