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It also increases production of decorin, dermatan sulfate, and chondroitin sulfate key components of the extracellular matrix that provide tissue structure and hydration (PMID: 12270842)
In severe cases, skin and underlying tissue can suffer necrosis (tissue death), requiring antibiotics or surgery to treat
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A subsequent study confirmed that miR-34a modulates DDP resistance by directly repressing MET (Zhang et al., 2016)
