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The major pathophysiological effects of an impaired or damaged endothelial glycocalyx are threefold: 1) increased vascular permeability, 2) reduced NO bioavailability and 3) increased inflammation

10.1016/J.EJPHAR.2018.01.046 211 ZhengW.LiX.ZhangT.WangJ

With an early diagnosis, timely abortive treatment, and appropriate prevention strategies, the suffering of children with CVS can be greatly reduced

The FDA and DOJ now treat it as an illegal drug and for good reason, given the unknown safety profile
