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We propose here that the mechanism by which MGO causes cognitive impairment is through microvascular impairment and BBB integrity loss
and enhanced cardiac injury in response to doxorubicin or ischemia-reperfusion (131, 231, 357, 402)
The cells were cultured in a CO2 incubator (5% CO 2 , 37 C) using Dulbeccos modified Eagles medium supplemented with 10% fetal bovine serum and 1% penicillin-streptomycin
13 For COVID-19 repurposing of an existing clinically approved drug, it is pivotal to demonstrate its antiviral, anti-inflammatory, and related effects against SARS-CoV-2 in cell-based systems in vitro
