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PKM2 promotes VEGF production in vascular endothelial cells, inhibits NF-B and downstream targets, and protects the vascular barrier [49]

These discoveries have given rise to the idea that bipolar disorder is a bioenergetic and metabolic disease with psychiatric manifestations, and that disruptions in the molecular and cellular signalling networks that regulate brain energy metabolism in a biphasic manner are a primary, sufficient cause of bipolar disorder-related phenomena [189]

The binding of the reactive intermediate to cellular macromolecules destroys the activity of those molecules, and can lead to compromised cell function and, ultimately, cell death

Hold the syringe needle-up and tap gently to move any remaining bubbles toward the needle