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Some authors suggest that impairments within the endogenous opioid system, such as those proposed here, may, over time, lead to the hyperactivation of pain pathways, and, therefore, transform normal stimuli into painful or heightened responses toward typical pain stimuli (allodynia and hyperalgesia, respectively) [137]
This contrasts sharply with corticosteroids and traditional immunosuppressants, which carry extensive lists of potential adverse effects
Science 381(6662):eabn4180, 2023
Pretreatment with arginine preserves intestinal barrier integrity and reduces bacterial translocation in mice
