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It directly affects the synthesis of glutathione when the dietary content of thiamin-containing amino acids is low

Cancer Res 30 , 15551566 (2024)

The significance of IDH1 and IDH2 produced NADPH can be made clear by pointing out that cells with low level IDH1 and IDH2 expression are more sensitive to oxidative stress than cells with higher levels of expression of these two enzymes

Membrane transporters in traumatic brain injury: pathological, pharmacotherapeutic, and developmental implications