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Preclinical in vitro hepatotoxicity assays with greater physiological relevance, sensitivity and longevity are required to more accurately predict and unlock the cause of DILI, or provide clarity where conflicting data create uncertainty

, in terms of TC, pH, or even a community-based response), we then exposed APAP and APAP-Cys to lysates from all these bacterial strains obtained after cell homogenizations using sonication ( 31 )

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