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Specifically, l-carnitine treatment can reduce synovitis by inhibiting AMPK-ACC-CPT1 pathway activation and showed an increase in fatty acid -oxidation, a lower lipid accumulation, and a noticeable improvement in mitochondrial function

IV: se recomiendan dosis de hasta 100 mg/kg/da divididas en 3-4 dosis (cada 6-8 h)

Three short-term trials showed positive effects of omega-3 supplementation on plasma biochemical parameters (e.g., reduced inflammatory cytokine expression, increased plasma EPA and DHA concentrations) compared to controls (161)

Cardiovascular Support (Off-label): Adjunctive therapy in certain cardiomyopathies where fatty acid metabolism is impaired