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John's wort extract shows significant affinity for adenosine, GABAa, GABAb, and glutamate receptors, and leads to a downregulation of -adrenergic receptors and an upregulation of serotonin 5-HT2 receptors in the brain1 5
Biochim Biophys Acta 1780:638651
NAC, supplemented externally, can restore these levels of glutathione
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