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[DOI] [PMC free article] [PubMed] [Google Scholar] 70.Tang D, Kang R, Berghe TV, Vandenabeele P, Kroemer G

Stress-induced Ca 2+ spikes serve as secondary messengers, activating calcium-dependent protein kinases (CDPKs) and calcineurin B-like proteins (CBLs) that regulate stress-responsive gene expression ( 2+ -mediated pathways by stabilizing ATP-dependent pumps and channels, ensuring controlled Ca 2+ fluxes during stress responses

Sublethal mitochondrial outer membrane permeabilization (MOMP) triggers cytochrome c release in a caspase-independent manner, activating heme-regulated inhibitor (HRI) kinase and enhancing ATF4-mediated integrated stress response (ISR) in residual DTPs [101, 120]

Polyphenols are found in many fruits and vegetables, and it has been suggested that diet therapy may be used to relieve depression (105)