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Additional information Peer review information Nature Communications thanks Keith Blackwell and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

Additionally, it reduces the mRNA levels of proinflammatory cytokines, such as interleukin-1 (IL-1), interleukin-6 (IL-6), and interleukin-12 (IL-12), both in muscle tissue in vivo and in adipose tissue cells in vitro , thereby alleviating high-fat diet-induced obesity and insulin resistance (37, 38), consistent with the results of facilitating the reduction of skeletal muscle lipid deposition and enhancing adipose tissue lipolysis (39) (Figure 3C)

Such influence may affect the biomarkers linked with the release of growth hormones in subjects

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