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The conditional essentiality observed for metZ under low pH further suggests that the earlier observation of the metZ essentiality on cholesterol likely resulted from the low pH growth conditions used in that study

2c-d and 3b-d, as well as Supplementary Fig

Furthermore, as expected, our data indicate the existence of a trade-off between glutathione biosynthetic activity and cellular viability and fitness beyond a certain threshold, suggesting that an optimum should be aimed for in a possible strain engineering strategy

Involvement of macrophage migration inhibitory factor (MIF) in experimental uric acid nephropathy