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Declining estrogen levels in the time leading up to menopause, known as perimenopause, can cause symptoms like unpredictable periods, mood swings, and sudden hot flashes

Evans, 1983

These pathways result in dysfunction of the vascular endothelium of the retina, marked by the loss of pericytes and endothelial cells, thinning of the basement membrane, increased retinal permeability, and the absence of neuroprotective molecules (182, 183)

Some antioxidants, such as those obtained from a balanced diet rich in fruits and vegetables, are an important part of a healthy pregnancy
