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Xu K, Li Y, Zhou Y et al (2024) Neuroinflammation in Parkinsons disease: focus on the relationship between miRNAs and microglia
When used at recommended doses (3-5 grams/day usually) it has been shown to be safe

Nutrient Deficiencies and Lab Results Low levels of B12, B6, or other B vitamins might warrant an initial round of weekly or biweekly injections until levels stabilize
However, the effectiveness of filtration depends on the pore size of the filter and the quality of the water being treated