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Under conditions of longterm hypoxia or insufficient glucose supply, the pathway of direct citrate production by KG helps maintain the stability of intracellular citrate levels
Horton, J
Nitric oxide formation versus scavenging: the red blood cell balancing act
The clinical titration starts at 0.25 mg weekly and increases every four weeks up to a maintenance dose of 2.4 mg weekly, though some research protocols extend up to 4.5 mg
