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However, many patients with autoimmune diseases eventually relapse and may suffer from life-threatening complications (3)

doubling up increases irritation without added benefit

doi: 10.1089/ars.2015.6508 189 Villa-CorreaYAIsaza-GuzmnDMTobn-ArroyaveSI
In a specific embodiment the linker is cleavable at a pH of less than 5.0
