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5 Conclusion Therefore, the mitochondrial dysfunction observed in aging is accompanied by the intracellular GSH/GSSG imbalance, a decrease of the H 2 S content in organelles and the expression levels of UCP3 , as well as the uncoupling of mtNOS with an increase in ROS production, disruption of Ca 2+ homeostasis, etc., which leads to the induction of mPTP with high conductance and causing cardiac dysfunction

The Journal of neuroscience : the official journal of the Society for Neuroscience 2016;36, 5448-5461, doi:10.1523/jneurosci.4247-15.2016

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That is why some clinics use peptides during the recovery window, when the barrier is open, and the skin is focused on repair