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There is no evidence that doses above 500mcg produce proportionally better results, and clinical trials using 1mg daily did not dramatically outperform lower doses

NNMT inhibition significantly increases energy expenditure, reduces body weight and white adipose mass, and improves insulin sensitivity

Safety data from over 900 clinical trial participants demonstrates that AOD-9604 is remarkably well-tolerated with a side effect profile indistinguishable from placebo in most studies

In the lorcaserin group, 22.6% of patients lost at least 10% of their body weight, as compared to 9.7% of patients in the placebo group [84]