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This finding underscores the potential therapeutic value of inhibiting the mtROS/HIF-2 signaling pathway and ameliorating the hypoxic microenvironment to attenuate the detrimental effects of CXCL4 in MS and other CXCL4-driven inflammatory disorders

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[529 530] For example, the AHC Model employed a 10-item AHC Health-Related Social Needs Screening Tool to enable providers to identify HRSNs in the five core domains (described in Table IX.D.-02) among community-dwelling Medicare, Medicaid, and dually eligible beneficiaries

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